SUPERANTIGEN

superantigen: translation

Antigens, mostly of microbial origin, that activate all T-lymphocytes that have a T-cell receptor with a particular V b sequence; as a consequence superantigens activate large numbers of T-cells. Are presented on MHC Class II but are not processed and though they bind with high affinity, not in the groove of the MHC molecule where peptides are normally bound. Presentation is not MHC-restricted. Staphylococcal enterotoxins are the best known superantigens and stimulate CD4+ T-cells in humans. The Mls gene product in mice can act as a self-superantigen.

superantigen: translation

Superantigens are bacterial proteins that stimulate the immune system much more extensively than do normal antigens. They stimulate T-cells to proliferate nonspecifically through simultaneous interaction with class II MHC proteins on antigen-presenting cells and variable regions on the b chain of the T-cell receptor complex. Examples include streptococcal scarlet fever toxins, staphylococcal toxic shock syndrome toxin-1, and streptococcal M protein.

суперантиген

суперантиген (процессированный в макрофаге антиген, имеющий высокий иммуногенный потенциал)

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