CYCLIC ADPRIBOSE

cyclic ADP-ribose: translation

(= cADPR; adenosine 5&’-cyclic diphosphoribose)

Second messenger synthesized by the multifunctional transmembrane ectoenzyme CD38 in various systems particularly platelets, microsomes and sea urchin eggs. Endogenous regulator of intracellular calcium. May act by regulating ryanodine receptor though other mechanisms are suggested.