AMINOGLYCOSIDE ANTIBIOTICS

aminoglycoside antibiotics: translation

Group of antibiotics active against many aerobic Gram negative and some Gram positive bacteria. Composed of two or more amino sugars attached by a glycosidic linkage to a hexose nucleus; polycationic and highly polar compounds. Inhibit bacterial protein synthesis by binding to a site on the 30S ribosomal subunit thereby altering codon-anticodon recognition. Common examples are streptomycin, gentamycin, amikacin, kanamycin, tobramycin, netilmicin, neomycin, framycetin.

aminoglycoside antibiotics: translation

(am\'ī-no-gli\'ko-saīd)

A group of antibiotics synthesized by Streptomyces and Micromonospora, which contain a cyclohexane ring and amino sugars; all aminoglycoside antibiotics bind to the small ribosomal subunit and inhibit protein synthesis.