CYTOCHALASINS

cytochalasins: translation

A group of fungal metabolites that inhibit the addition of G-actin to a nucleation site and therefore perturb labile microfilament arrays. Cytochalasin B inhibits at around 1 m g/ml but at about 5 m g/ml begins to inhibit glucose transport. Cytochalasin D affects only the microfilament system and is therefore preferable.