chaperones: translation
Cytoplasmic proteins of both prokaryotes and eukaryotes (and organelles such as mitochondria) that bind to nascent or unfolded polypeptides and ensure correct folding or transport. Chaperone proteins do not covalently bind to their targets and do not form part of the finished product. Heat-shock proteins are an important subset of chaperones. Three major families are recognized, the chaperonins (groEL and hsp60), the hsp70 family and the hsp90 family. Outside these major families are other proteins with similar functions including nucleoplasmin, secB, and T-cell receptor-associated protein.