DH DOMAIN

(= Dbl homology domain)

Domain of around 250 amino acids found in Dbl, Vav and a family of other Dbl-family proteins (Lfc, Lsc, Ect2, Dbs, Brx). DH domains are invariably located immediately N-terminal to PH domain and the membrane localization and enzymatic activity of the DH domain requires the PH domain for normal function.