EGFLIKE DOMAIN

Region of 30-40 amino acids containing 6 cysteines found originally in EGF, and also in a range of proteins involved in cell signalling. Examples: TGF a, amphiregulin, urokinase, tissue plasminogen activator, complement C6-C9, fibronectin, laminin (each subunit at least 13 times), nidogen, selectins. It is also found in the Drosophila gene products: Notch (36 times) Delta, Slit, Crumbs, Serrate.